1988: Raymond Dattwyler associates immunosuppression with borrelial lipoproteins.
In this report, Dattwyler states:
"Figure 1 demonstrates that there was a marked and highly significant inhibition ( p < 0.0005) of invivo endogeneous NK activity in two patient populations: (1) patients in the early stages of Lyme disease (ECM stage) and before treatment, and (2) patients exhibiting chronic active stages of the disease."
Natural Killer Cell activity is muted, and Dattwyler also says Borrelial supernatant (where the fatty Osps are) does this too. That means it was known in 1988 that Borrelia and its shed mucopeptides or lipoproteins cause immune system blunting.