2001: Klempner's fake retreatment study in which 2/3 of the participants had not received prior treatment.
Mark Klempner’s 2001 long-term treatment study (90 days total) was and always will be scientific fraud.
There were never enough participants; he used invalid methods; he was lying about his previous findings; he was also lying about finding "no DNA-positive patients" among the previously treated because he threw the DNA positive victims out of the study. Two-thirds of the patients had never been treated before; he never reported what primers he used; he did not look for commonly activated viruses in these patients that are well known to be reactivated in the presence of immune suppression; and no scientifically valid assessments of outcomes of this standard of care "study" were performed. The result was that extended treatments were not beneficial to patients.
This became the essence of the IDSA "guidelines," whereas ILADS is not aware or does not care that OspA alone caused the same post-sepsis outcome that we call "Chronic Lyme."